Taking almotriptan with certain depression medications, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome. These symptoms may include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.

 

Taking almotriptan with ergot medications can increase your risk of dangerous side effects. Do not take almotriptan and ergot medications within 24 hours of each other.

 

Taking almotriptan with erythromycin can raise the level of almotriptan in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of almotriptan.

 

Taking almotriptan with itraconazole can raise the level of almotriptan in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of almotriptan.

 

Taking almotriptan with ketoconazole can increase the level of almotriptan in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of almotriptan.