Some Amerge warnings and precautions concern an increased risk for serious heart problems with the drug. Other precautions and warnings to be aware of before taking Amerge involve the risks of taking the drug with certain antidepressants. Before taking Amerge, you should tell your healthcare provider if you have heart problems of any kind, high blood pressure, or a history of a stroke. You should not take Amerge if you have a history of heart disease.

• Heart problems of any kind, especially a history of heart disease, angina, an irregular heart rhythm, or a heart attack
• A history of stroke, transient ischemic attack (TIA or "mini-stroke"), or other bleeding in the brain (such as a subarachnoid hemorrhage)
• High blood pressure (hypertension)
• High cholesterol
• Certain blood vessel conditions, such as peripheral vascular disease, ischemic bowel disease, or Raynaud's phenomenon
• Diabetes
• Kidney problems, including kidney failure (renal failure)
• Liver problems, including liver failure or cirrhosis
• Depression
• Gone through menopause
• Any allergies, including allergies to foods, dyes, or preservatives.
   

• Are pregnant or thinking of becoming pregnant
• Are breastfeeding
• Smoke
• Have a family history of heart disease.