Taking Axert with certain depression medications, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.

 

Taking Axert with ergot medications can increase your risk of dangerous side effects. Do not take Axert and ergot medications within 24 hours of each other.

 

Taking Axert with erythromycin can raise the level of Axert in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of Axert.

 

Taking Axert with itraconazole can increase the level of Axert in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of Axert.

 

Taking Axert with ketoconazole can raise the level of Axert in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of Axert.

 

It can be very dangerous to combine MAOIs with triptans (migraine medications similar to Axert). Taking these medicines together can greatly increase the level of the migraine medication in your blood, increasing your risk of dangerous side effects. You should not take most triptans if you have taken an MAOI within the past two weeks.

 

However, MAOIs seem to have less of an effect on Axert. The manufacturer does not warn against using the two medications together and does not recommended changing the dose of Axert if you are taking them together. However, be sure to talk with your healthcare provider before combining Axert with an MAOI, as it is best to be more cautious when using these medications together.