Axert can potentially interact with a number of other medications, including ergot medications, MAOIs, and certain antidepressants. Some of these drug interactions with Axert can increase your risk of dangerous side effects, or can result in a condition called serotonin syndrome. Serotonin syndrome can be very dangerous and includes symptoms such as confusion, hallucinations, and difficulty walking. Be sure to talk with your healthcare provider about any Axert drug interactions that may apply to you.