Cambia Warnings and Precautions

Some Cambia Warnings and Precautions

Some warnings and precautions to be aware of with Cambia include:
 
  • There is a "Medication Guide" (an FDA-approved handout) that should be dispensed along with Cambia. Be sure to read the medication guide before using this medication and periodically thereafter.
     
  • All NSAIDs, including Cambia, have been linked to cardiovascular events, such as heart attacks or strokes. People who have cardiovascular disease or cardiovascular risk factors appear to be at greater risk. To decrease the chances of these problems occurring, you should take the smallest effective dose for the shortest period of time.
Be sure to call 911 if you notice heart attack symptoms or stroke symptoms such as:
    • Chest pain
    • Shortness of breath
    • Weakness
    • Slurring of speech. 

 

  • Liver damage can occur in people taking Cambia. Contact your healthcare provider immediately if you notice things such as:

 

    • Nausea
    • Tiredness
    • Lethargy
    • Itchy or yellowing skin
    • Abdominal (stomach) pain
    • Flu-like symptoms. 
It may be a good idea for your healthcare provider to monitor your liver by checking your liver enzymes (using a simple, standard blood test).
  • All NSAIDs, including Cambia, may cause high blood pressure or make it worse in people who already have it. Therefore, Cambia should be used with caution in people with high blood pressure.
     
  • All NSAIDs, including Cambia, may cause congestive heart failure or fluid retention. Contact your healthcare provider if you notice unexplained weight gain or swelling while taking this drug. Also, Cambia should be used with caution in people with heart failure.
     
  • All NSAIDs, including Cambia, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines (called perforations). Extreme caution should be used if Cambia is prescribed for people with a history of ulcers or gastrointestinal bleeding. 
To decrease the risk of these problems, you should take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
    • Abdominal (stomach) pain
    • Indigestion
    • Black, tarry stools
    • Vomiting blood. 
It is important to understand that Cambia can cause this problem.
  • Cambia can interact with certain medications (see Cambia Drug Interactions).
     
  • Kidney damage can occur in people taking NSAIDs, including Cambia. This occurrence is more common in the elderly, as well as in people with kidney disease, heart failure, liver problems, and those taking a diuretic or ACE inhibitor.
     
  • NSAIDs, including Cambia, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice things such as difficulty breathing or swelling of the face and throat.
     
  • In rare cases, people taking Cambia can develop a serious rash. If you notice an unexplained rash or develop blisters, fever, or itchy skin, stop taking Cambia and call your healthcare provider right away.
     
  • Cambia contains phenylalanine. This is important for people with phenylketonuria, who must limit their intake of phenylalanine. Each packet of Cambia contains 25 mg of phenylalanine.
     
  • There have been reports of anemia in people taking NSAIDs. Therefore, if you are taking Cambia for an extended period of time and show signs of anemia (such as pale skin or extreme fatigue), talk to your healthcare provider.
     
  • It is possible that Cambia could worsen asthma, especially in people with aspirin-sensitive asthma.
     
  • Cambia is a pregnancy Category C medicine, meaning that it might not be safe during pregnancy, although the full risks are currently unknown (see Cambia and Pregnancy for more information).
     
  • It is unknown if Cambia passes through breast milk. Therefore, if you are breastfeeding a child, check with your healthcare provider (or your child's healthcare provider) before taking Cambia (see Cambia and Breastfeeding).
     
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