Divalproex is commonly prescribed for migraine prevention and the treatment of epilepsy and manic episodes associated with bipolar disorder. The drug works by affecting sodium channels in the brain and increasing the amount of a certain brain chemical (GABA). Various divalproex products are available, including delayed-release tablets and sprinkle capsules. Possible side effects include headaches, shakiness, and drowsiness.
- Mania -- The medication is approved to treat manic episodes associated with bipolar disorder (manic depression).
- Epilepsy -- Divalproex is approved to treat complex partial seizures and simple or complex absence seizures.
- Migraines -- The medication is approved to help prevent migraine headaches, but it does not help treat a headache once it starts.
Several different divalproex products are available. This article refers to regular divalproex delayed-release tablets and sprinkle capsules (Depakote® Sprinkle capsules). For information on the long-acting form, see Divalproex ER.
(Click What Is Divalproex Used For? for more information on specific uses, including possible off-label uses.)
Divalproex is made by Abbott Pharmaceuticals.