Divalproex

Divalproex is a prescription medicine that is used for migraine prevention and the treatment of epilepsy and manic episodes associated with bipolar disorder. The drug works by affecting sodium channels in the brain and increasing the amount of a certain brain chemical (GABA). There are various divalproex products available, including delayed-release tablets and sprinkle capsules. Some possible side effects of divalproex include headaches, shakiness, and drowsiness.

 

What Is Divalproex?

Divalproex sodium (Depakote®) is a prescription medication used to treat the following conditions:
 
  • Mania -- divalproex is approved to treat manic episodes associated with bipolar disorder (manic depression)
     
  • Epilepsy -- divalproex is approved to treat complex partial seizures and simple or complex absence seizures
     
  • Migraines -- divalproex is approved to help prevent migraine headaches (but it does not help treat a headache once it starts).
     
There are several different divalproex products available. This article refers to regular divalproex delayed-release tablets and sprinkle capsules (Depakote® Sprinkle capsules). For information on the long-acting form, see Divalproex ER® (divalproex ER).
 
(Click What Is Divalproex Used For? for more information on specific divalproex uses, including possible off-label uses.)
 

Who Makes Divalproex?

Divalproex is made by Abbott Pharmaceuticals.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;