Side Effects of Divalproex

In clinical trials, some of the most commonly reported side effects of divalproex included shakiness, nausea, headaches, and drowsiness. While most divalproex side effects are minor and don't require medical attention, you should let your healthcare provider know if you develop any serious problems. Potentially dangerous divalproex side effects can include depression, signs of pancreatitis, and worsening of seizures.

 

An Introduction to Divalproex Side Effects

As with any medicine, side effects are possible with divalproex sodium (Depakote®); however, not everyone who takes the medication will experience side effects. In fact, most people tolerate divalproex quite well. If side effects do occur, in most cases they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with divalproex. Your healthcare provider can discuss a more complete list of divalproex side effects with you.)
 

Common Side Effects With Divalproex

Divalproex has been studied thoroughly in clinical trials. In these studies, the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In these studies, some of the most common divalproex side effects included:
 
  • Shakiness (tremors) -- in up to 57 percent of people
  • Nausea -- up to 48 percent
  • Headaches -- up to 31 percent
  • Drowsiness -- up to 30 percent
  • Vomiting -- up to 27 percent
  • Weakness -- up to 27 percent
  • Dizziness -- up to 25 percent.
     
Some other common side effects, occurring in 5 percent to 24 percent of people, included:
 
(Side Effects of Divalproex Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;