Benefits of Feverfew (Cont.)

How Does Feverfew Work?

It is not known exactly how feverfew works. The leaves (the active part of the plant) contain numerous different chemicals that may have medicinal properties. The parthenolide component of feverfew may be responsible for many of its effects. Parthenolide inhibits several enzymes and chemicals in the body that cause pain, inflammation, and other problems. Specifically, parthenolide may inhibit cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF), and interleukin 1 (IL-1). Several other chemicals in feverfew may contribute to its effects as well.
 

Feverfew Use in Children

It is not known if feverfew is safe for children. As with many medications or supplements, children may be more sensitive to the effects and toxicities of feverfew.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;