Headache Home > Alsuma

If you experience migraines or cluster headaches, Alsuma may help relieve your symptoms. This prescription medicine comes in the form of an injection that is given just below the skin. Most people inject this medicine themselves. It works by constricting blood vessels in the head that become wider than usual during a migraine or cluster headache. Side effects include skin reactions at the injection site and tingling.

What Is Alsuma?

Alsuma™ (sumatriptan) is a prescription medication approved for treating migraine headaches and cluster headaches. It comes in an autoinjector device and is injected just below the skin (subcutaneously).
(Click Alsuma Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Alsuma is made by Meridian Medical Technologies™, Inc.

How Does Alsuma Work?

Alsuma belongs to a class of migraine medications called 5-HT agonists, or more commonly known as "triptans." During a migraine or cluster headache, some of the blood vessels in the head open wider than normal (dilate). Alsuma works by narrowing these blood vessels, helping to return them to their normal state. This action helps to relieve symptoms of cluster headaches or migraines.

When and How to Use It

Some general considerations to keep in mind during treatment with Alsuma include the following:
  • Alsuma comes in injectable form. It is injected just below the skin. Most people inject this medication themselves.
  • Talk with your healthcare provider about which areas of the body you may use for the injection. You will need an area that has an adequate layer of fat and skin, as this medication should not be injected into a muscle or vein. In most cases, an arm or thigh is used.
  • Your healthcare provider should take the time to teach you exactly how to use the Alsuma autoinjector. If you have questions, ask your healthcare provider or pharmacist before using this medication.
  • The autoinjector works automatically when you press the device hard against your skin. Hold the device in place for five seconds after you feel the injection.
  • If your headache comes back or does not go away, a second dose of Alsuma can be given after waiting at least one hour after the first dose. Let your healthcare provider know if this drug does not work completely after one dose.
  • For this medication to work properly, it must be used as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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