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A few common side effects of Imitrex include chest tightness or pressure; dizziness; and abnormal sensations, such as tingles, warmth, or numbness. Side effects that you should report to your healthcare provider include shortness of breath; bloody diarrhea; or sudden, severe stomach pain. Decreased or increased blood pressure, breast tenderness, and asthma are rare, but can occur.

Imitrex Side Effects: An Introduction

As with any medicine, side effects are possible with Imitrex® (sumatriptan succinate). However, not everyone who takes the drug will have problems. In fact, most people tolerate it well. If people do develop side effects, in most cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Imitrex. Your healthcare provider can discuss a more complete list of Imitrex side effects with you.)

Common Side Effects of Imitrex

Imitrex has been studied thoroughly in clinical trials, with many people having been evaluated. In these studies, the side effects that occurred in a group of people taking the drug were documented and then compared to the side effects that occurred in another group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
Based on these studies, the most common Imitrex side effects include:
  • Injection site reactions (including redness, pain, or swelling) -- occurring in up to 59 percent of people who took the injected form
  • Abnormal sensations, including tingles, warmth or burning, pressure, tightness, or numbness -- up to 42 percent
  • Bad or unusual taste in the mouth -- up to 25 percent of people who took Imitrex Nasal Spray
  • Dizziness or a spinning sensation (vertigo) -- up to 12 percent
  • Flushing (redness of the skin, especially the face) -- up to 7 percent
  • Chest tightness or pressure -- up to 5 percent
  • Weakness -- up to 5 percent
  • Neck pain -- up to 5 percent.
Other common side effects, occurring in 1 to 5 percent of people, include:
  • Ear, nose, or throat discomfort
  • Drowsiness
  • Muscle pain or cramps
  • Anxiety
  • Abdominal pain (stomach pain)
  • Difficulty swallowing
  • Jaw pain
  • Sweating
  • Decreased salivation
  • Drowsiness.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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