Treximet is a medication licensed for the treatment of migraine headaches. It is a combination drug that contains naproxen (an NSAID) and sumatriptan (a triptan), medications that work by inhibiting the production of inflammatory chemicals and by narrowing the blood vessels that become dilated during a migraine. The medication, which is available by prescription, should be taken as soon as a migraine starts.
Sumatriptan belongs to a class of migraine medications called 5-HT agonists (or more commonly known as "triptans"). During a migraine headache, some of the blood vessels in the head become dilated (wider open than they usually are). Sumatriptan works by narrowing these blood vessels, helping them return to their normal state. This action helps to relieve migraine symptoms.
Naproxen sodium belongs to a group of medications known as nonsteroidal anti-inflammatory drugs (NSAIDS). It helps to relieve migraine pain by inhibiting the production of inflammatory chemicals known as prostaglandins.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Treximet [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2008 April.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed April 21, 2008.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
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