Headache Home > Zecuity

A healthcare provider may prescribe Zecuity to help treat migraine headaches. This medication works by binding to certain receptors on the blood vessels and nerves, which causes them to return to their normal state. This product comes as a patch that is applied directly on the skin when a migraine starts. Side effects may include itching, warmth, and pain at the application site.


What Is Zecuity?

Zecuity™ (sumatriptan transdermal) is a prescription medication approved to treat migraine headaches. It is a transdermal system (TDS), which is a patch that is applied directly on the skin.
Zecuity is used to treat acute migraine attacks. It will not prevent a migraine from occurring or reduce the number of attacks you have. The patch uses two coin cell lithium batteries to produce a low electrical current to deliver the drug through the skin.
(Click Zecuity Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Zecuity is manufactured by NuPathe, Inc.

How Does Zecuity Work?

Zecuity belongs to a group of medicines known as serotonin (5-HT) agonists, more commonly known as "triptans." Migraine symptoms are thought to occur when blood vessels in the head widen and/or nerves in the head release certain substances that can trigger inflammation.
Like other triptans, Zecuity works by binding to 5-HT receptors on these blood vessels and nerves. This causes the blood vessels to narrow and return to their normal state, and prevents the nerves from releasing the inflammation-causing substances. These actions are thought to help relieve migraine symptoms.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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