Topiramate Dosing for Epilepsy (Adjunctive Therapy)
The recommended topiramate dose for epilepsy as adjunctive therapy (in combination with other epilepsy medications) varies depending on age and the type of seizures. For people age 17 and over, the recommended dose is 100 mg to 200 mg twice daily for partial seizures or 200 mg twice daily for generalized tonic-clonic seizures. The dose should be slowly increased up to the recommended dose, as when used for monotherapy.
For children age 2 to 16, the recommended dose of topiramate is 5 mg to 9 mg per kg of weight (about 2.3 to 4 mg per pound), split into two doses per day. The starting dose should be low and should be increased slowly as directed by your child's healthcare provider.
Some considerations for people taking topiramate include:
- Topiramate comes in tablets or "sprinkle" capsules. It is taken by mouth, usually twice a day.
- Topiramate sprinkle capsules can be opened and the contents sprinkled on a spoonful of soft food and swallowed (not chewed) immediately. They can also be swallowed whole.
- It does not matter if you take topiramate with or without food.
- For people with kidney disease (such as kidney failure), the recommended dose is lower (half the usual dose).
- Topiramate should be taken at the same times each day to maintain an even level of the drug in your blood.
- For the medication to work properly, it must be taken as prescribed. Topiramate will not work if you stop taking it.
- If you are unsure about anything related to topiramate or your topiramate dosage, please talk to your doctor, nurse, or pharmacist.