Treximet Drug Interactions
Taking Treximet with ergot medications can increase your risk of dangerous side effects. Do not take Treximet and ergot medications within 24 hours of each other.
Lithium (Eskalith, Lithobid)
The naproxen in Treximet can increase the level of lithium in your blood, increasing your risk of lithium toxicity. Do not combine Treximet with lithium without your healthcare provider's approval and supervision.
Methotrexate (Rheumatrex, Trexall)
The naproxen in Treximet can increase the level of methotrexate in your blood, increasing your risk of serious methotrexate side effects. Do not combine Treximet with methotrexate without your healthcare provider's approval and supervision.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Treximet contains an NSAID medication (naproxen). Taking more than one NSAID at a time can increase your risk of side effects, such as dangerous internal bleeding.
Probenecid can increase the level of the naproxen component of Treximet in your blood, increasing your risk of side effects. Check with your healthcare provider before taking these medications together.
Taking Treximet with other triptans can increase your risk of serous side effects. These medications should not be taken within 24 hours of each other.
Warfarin (Coumadin, Jantoven)
In general, it is not recommended to take Treximet with warfarin. Both warfarin and naproxen (one of the components of Treximet) can increase the risk of bleeding, including dangerous internal bleeding. Check with your healthcare provider before combining Treximet with warfarin.