Treximet Drug Interactions

If aspirin or diuretics are taken in combination with Treximet, drug interactions could occur. Some interactions can decrease the effectiveness of the medicines, while others can increase your risk for developing dangerous side effects. Other medications that may cause drug interactions with Treximet include nonsteroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors, and monoamine oxidase inhibitors (MAOIs).

 

An Introduction to Treximet Drug Interactions

Treximet™ (sumatriptan/naproxen sodium) can potentially interact with several other medications. Some of the medicines that may lead to Treximet interactions include:
 
  • ACE inhibitors, including:

 

 

  • Aspirin (Bayer® and others)
     
  • Diuretics, such as:

 

 

  • Ergot medications, such as:

 

    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergotamine (Bellamine S, Cafergot®, Ergomar®)
    • Pergolide (Permax®)

 

  • Lithium (Eskalith®, Lithobid®)
     
  • Methotrexate (Rheumatrex®, Trexall™)
     
  • Monoamine oxidase inhibitors (MAOI inhibitors), including:

 

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

 

 

 

 

  • Warfarin (Coumadin®, Jantoven®).
     
(Treximet Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;