Effects of Treximet

In one study, up to 65 percent of people with migraines had no (or mild) pain within two hours of taking Treximet, compared to just 55 percent of those taking sumatriptan alone, 44 percent of those taking naproxen sodium alone, or 28 percent of those taking a placebo (a "sugar pill" with no active ingredients). Additionally, Treximet was more effective for keeping people pain-free for 24 hours after taking a dose, compared to sumatriptan, naproxen sodium, or placebo (in other words, it seemed to work better for preventing the migraine from returning).

When and How to Use It

Some general considerations for when and how to use the medication include the following:
  • Treximet comes in tablet form. It is taken by mouth as soon as possible once a migraine starts.
  • Swallow Treximet tablets whole with a drink of water or other fluids.
  • Treximet can be taken with or without food. Because one of the components of Treximet (naproxen sodium) can be irritating to the stomach, it may be a good idea to take your dosage with a little food (although this may not be possible due to nausea from the migraine).
  • Do not take two doses of Treximet within two hours of each other.
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.

Dosing Information

There is only one standard recommended dose for Treximet. As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Treximet Dosage for more information.)
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Treximet Medication Information

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