It is important to talk to your healthcare provider about Treximet warnings and precautions, as it is possible to develop side effects or complications while taking the medication. Treximet could increase the risk of heart attacks or strokes, bleeding, and seizures. You should avoid taking Treximet if you have untreated high blood pressure, liver problems, or a history of angina.

• Heart problems of any kind, especially a history of heart disease, angina, an irregular heart rhythm, or a heart attack
• A history of stroke, transient ischemic attack (TIA or "mini-stroke"), or other bleeding in the brain (such as a subarachnoid hemorrhage)
• Congestive heart failure (CHF)
• High blood pressure (hypertension)
• High cholesterol
• Diabetes
• Certain blood vessel conditions, such as peripheral vascular disease, ischemic bowel disease, or Raynaud's phenomenon
• Kidney problems, including kidney failure (renal failure)
• Liver problems, including liver failure or cirrhosis
• A history of seizures or epilepsy
• Asthma
• Any allergies, including allergies to foods, dyes, or preservatives.
   

• Are pregnant or thinking of becoming pregnant
• Are breastfeeding
• Smoke
• Have a family history of heart disease.