Treximet is a medication licensed for the treatment of migraine headaches. It is a combination drug that contains naproxen (an NSAID) and sumatriptan (a triptan), medications that work by inhibiting the production of inflammatory chemicals and by narrowing the blood vessels that become dilated during a migraine. The medication, which is available by prescription, should be taken as soon as a migraine starts.

What Is Treximet?

Treximet™ (sumatriptan/naproxen sodium) is a prescription medication used to treat migraine headaches. It will not help to prevent migraines but can help treat a migraine that is already occurring. Treximet contains two different medications to help relieve migraine pain.
(Click Treximet Uses for more information on what the medication is used for, including possible off-label uses.)

Who Makes It?

Treximet is made by GlaxoSmithKline.

How Does It Work?

Treximet contains two separate medications, sumatriptan (the same medication in Imitrex®) and naproxen sodium.
Sumatriptan belongs to a class of migraine medications called 5-HT agonists (or more commonly known as "triptans"). During a migraine headache, some of the blood vessels in the head become dilated (wider open than they usually are). Sumatriptan works by narrowing these blood vessels, helping them return to their normal state. This action helps to relieve migraine symptoms.
Naproxen sodium belongs to a group of medications known as nonsteroidal anti-inflammatory drugs (NSAIDS). It helps to relieve migraine pain by inhibiting the production of inflammatory chemicals known as prostaglandins.
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Treximet Medication Information

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