Zomig drug interactions can increase your risk of dangerous side effects or cause a group of symptoms called serotonin syndrome (which can include confusion, hallucinations, and difficulty walking), among other things. A few of the drugs that can potentially interact with Zomig include ergot medications, type A monoamine oxidase inhibitors (MAO-A inhibitors), and certain antidepressants. You should talk with your pharmacist or healthcare provider about any drug interactions with Zomig that may apply to you.