Zomig Warnings and Precautions

Some Zomig Warnings and Precautions

Some Zomig warnings and precautions to be aware of include:
If you have risk factors for heart disease (see Heart Disease Risk Factors), it is also strongly recommended that you take your first dose of Zomig in your healthcare provider's office so that he or she can monitor your heart. You should also have your heart checked periodically while taking Zomig.
  • In some cases, a stroke or transient ischemic attack ("mini stroke") can be misdiagnosed as a migraine. Your healthcare provider should make sure you are not having a stroke, especially if you have never had migraines in the past (see Stroke Symptoms for more information on the symptoms of a stroke).
  • You should not take Zomig if you have an irregular heart rhythm (arrhythmia), including Wolff-Parkinson-White syndrome.
  • If you have chest pain or tightness in the jaw or neck after taking Zomig, contact your healthcare provider immediately. These side effects are fairly common with Zomig and are not usually serious. However, your healthcare provider may need to make sure you are not having heart problems.
  • Medications like Zomig can cause blood vessels in the arms, legs, colon (large intestine), and other locations to spasm. This can cause a decrease in blood flow to these areas. Symptoms will vary based on the location. For example, a spasm in the colon can lead to severe abdominal pain (or stomach pain) or bloody diarrhea.
  • Taking Zomig with certain antidepressants, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can increase your risk of a dangerous group of symptoms called serotonin syndrome. Do not use Zomig with depression medications without first discussing it with your healthcare provider. Contact your healthcare provider immediately if you have any possible symptoms of serotonin syndrome, including:


    • Confusion
    • Seeing or hearing things that are not really there (hallucinations)
    • A fast heartbeat (tachycardia)
    • Feeling faint
    • A fever
    • Sweating
    • Muscle spasms
    • Difficulty walking
    • Diarrhea.


  • Zomig can cause an increase in blood pressure. You should not take Zomig if you have untreated high blood pressure (hypertension).
  • Zomig ZMT® tablets (but not regular Zomig tablets) contain phenylalanine. This is important for people with phenylketonuria, who must limit their phenylalanine intake.
  • Tell your healthcare provider if you have liver problems (including liver failure or cirrhosis) before taking Zomig. This is important because the liver helps to remove Zomig from the body.
  • Zomig is considered a pregnancy Category C medication. This means that Zomig may not be safe for use during pregnancy. Talk with your healthcare provider before using Zomig if you are pregnant (see Zomig and Pregnancy for more information).
  • It is not known if Zomig passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this.
  • Zomig can interact with certain other medications (see Zomig Drug Interactions).
Know the Signs - Concussion Safety

Zomig Drug Info

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